MSH has 10 TENs composed of approximately 600 members from 45 countries. Over two-thirds of members are based in field-based projects supported by MSH. Each TEN is focused on a technical area, such as reproductive, maternal, newborn, and child health, HIV/AIDS, and tuberculosis; a health systems function, such as leadership and governance, health care finance, and human resources for health; or cross-cutting topics, such as gender, youth, monitoring and evaluation, and country operations. A review of the literature, development of an operational framework, assessment, and analysis with case examples provide important insights into how the TENs can be used to collaborate with peers around the world and add value to the agency’s mission and vision. MSH now can identify which TENs are ready to be pushed to the next level of functionality to meet MSH’s evolving performance and learning priorities.