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To improve tuberculosis (TB) diagnosis, many national TB programmes have committed to deploying Xpert® MTB/RIF. Implementation of this relatively new technology has suffered from a lack of comprehensive technical assistance, however, including the formulation of policies and plans to address operational issues. While providing technical assistance, we observed numerous operational challenges in the implementation and scale-up of Xpert in five sub-Saharan African countries: low coverage, poor laboratory infrastructure, limited access, poor linkages to treatment, inadequate data on outcomes, problems with specimen transport, diagnostic algorithms that are not aligned with updated World Health Organization recommendations on target patient groups and financing challenges. We recommend better country preparedness and training, laboratory information and quality systems, supply management and referral mechanisms.

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This technical brief presents analysis of the impact of differential fertility decline among wealth quintiles on population age structure in four African countries, the trajectory of these trends through 2050, and the impact on access to economic opportunity.

Sleeping sickness (human African trypanosomiasis [HAT]) is a neglected tropical disease with limited treatment options that currently require parenteral administration. In previous studies, orally administered pafuramidine was well tolerated in healthy patients (for up to 21 days) and stage 1 HAT patients (for up to 10 days), and demonstrated efficacy comparable to pentamidine. This was a Phase 3, multi-center, randomized, open-label, parallel-group, active control study where 273 male and female patients with first stage Trypanosoma brucei gambiense HAT were treated at six sites: one trypanosomiasis reference center in Angola, one hospital in South Sudan, and four hospitals in the Democratic Republic of the Congo between August 2005 and September 2009 to support the registration of pafuramidine for treatment of first stage HAT in collaboration with the United States Food and Drug Administration. The overall cure rate at 12 months was 89% in the pafuramidine group and 95% in the pentamidine group; pafuramidine was non-inferior to pentamidine as the upper bound of the 95% confidence interval did not exceed 15%. The safety profile of pafuramidine was superior to pentamidine; however, 3 patients in the pafuramidine group had glomerulonephritis or nephropathy approximately 8 weeks post-treatment. Two of these events were judged as possibly related to pafuramidine. Despite good tolerability observed in preceding studies, the development program for pafuramidine was discontinued due to delayed post-treatment toxicity.

MSH worked with school, community, and government partners to lead a pilot intervention with 30 adolescent girls (ages 13 to 19) at Government Day Secondary School, Tal in Billiri, Gombe State in northeast Nigeria for six months from 2014 to 2015.

"Improving Medicines Access and Use for Child Health—A Guide to Developing Interventions" represents an up-to-date and practical resource for those developing interventions to improve access to and use of medicines for child illness. It targets groups working in community organizations, health facilities, and district health offices, or within larger health systems.

Regional bodies have become active contributors to the development of Africa's health sector in the last 10 to 15 years.

Despite the growing international trend towards increased regional multilateralism, integration, and cooperation in health and other sectors, there is a limited body of literature examining the relationships, power dynamics, limitations, and strategic advantages of regional bodies.

This brief discusses the impact of disease on trade, economic growth and commerce, with particular reference to the recent Ebola outbreak in West Africa.

In order for governments and organizations to adopt, implement, and scale up community health programs, knowledge of the wide typology of Community Health Worker (CHW) models and their associated incentive mechanisms is critical.

In Madagascar, community health workers play an essential part in improving access to quality health services in the context of a weak public sector and a severe shortage of trained healthcare workers.

Increasingly a part of corporations' business strategies, corporate social responsibility (CSR) is an expression of the business desire to create value for both the corporation and the community in which it operates.

When planned and used appropriately, financial incentives have proven effective in improving utilization and quality of maternal and child care.

In November 2015, the African Union Commission released this status report on maternal and child health. Developed with support from the African Strategies for Health (ASH) project, the status report is part of the African Union's contribution to enhancing MNCH on the continent. This is the third in a series of status reports prepared since 2012.

To enhance cross-country learning around maternal death surveillance and response (MDSR), African Strategies for Health developed two country-specific case studies which document MDSR implementation experiences in Burkina Faso and Malawi. These case studies were developed for inclusion in the WHO Global MDSR Implementation Report and can be accessed on the WHO website. 

To ensure universal access to sexual and reproductive health services, a range of systems and service delivery interventions, identified as high impact practices (HIPs), help family planning programs focus their efforts and maximize resources to achieve broadest reach and greatest impact.

This report documents the outcomes of the Africa Regional Meeting on Digital Health for Overcoming Barriers to Ending Preventable Child and Maternal Deaths and Achieving Universal Health Coverage. From May 12-15 2015, over 150 government, private sector, and donor participants came together in Lilongwe, Malawi to exchange ideas and information on how to adopt and expand digital health technol

This report documents key topics presented and discussed at the first ever ministerial-level stakeholders meeting, "Investing in Technology and Innovations for Human Development in Africa," held on October 14, 2014 in Rabat, Morocco.

This report documents the proceedings of the International Conference of the African Evaluation Association in Yaounde, Cameroon, held March 3-7, 2014.

This report documents key topics presented and discussed at the Integrated Disease Surveillance and Response 2013 Pre-Conference Workshop.

Mobile and wireless technologies assist health projects in accurately assessing the needs of a target population, collecting and disseminating relevant information, and delivering cost effective health services. This fourth volume of the mHealth compendium, published in October 2014, is a collection of 31 case studies.

Integrated community case management (iCCM), the delivery of timely and low-cost interventions at the community level by community health workers, is an effective strategy for expanding access for the treatment of diarrhea, pneumonia, and malaria, which are the leading causes of child mortality and result in nearly 44 percent of deaths worldwide in children under five years old.

Integrated community case management (iCCM) is considered to be an effective strategy for expanding the treatment of diarrhea, pneumonia, and malaria, which are the leading causes of child mortality and result in nearly 44 percent of deaths worldwide in children under five years old.

MSH used USAID's iCCM Costing and Financing Tool to estimate the costs and impact of iCCM implementation and scale-up in two states of Nigeria: Kebbi and Benue. This study aims to forecast the costs and impact of introducing the iCCM program in Benue and Kebbi states.

Integrated community case management (iCCM) is considered to be an effective strategy for expanding the treatment of diarrhea, pneumonia, and malaria, which are the leading causes of child mortality and result in nearly 44 percent of deaths worldwide in children under five.