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Background: The Ministry of Health in Malawi is implementing a pragmatic and innovative approach for the management of all HIV-infected pregnant women, termed Option B+, which consists of providing life-long antiretroviral treatment, regardless of their CD4 count or clinical stage. Our objective was to determine if Option B+ represents a cost-effective option.

Rationale, aims, and objectives: For a successful patient outcome, a high level of adherence to antiretroviral therapy (ART) is needed. A 2008 report in Tanzania indicated poor clinic attendance and a high lost to follow-up rate as major threats to optimal ART program effectiveness.

In developing countries, particularly in Africa, the provision of health services leans heavily towards today’s epidemics, including HIV and AIDS, malaria, tuberculosis and other infectious diseases. This calls for different approaches to the implementation of interventions from a public health perspective.

Background: Mortality and morbidity among HIV-exposed children are thought to be high in Malawi. We sought to determine mortality and health outcomes of HIV-exposed and unexposed infants within a PMTCT program.

The national scale up of antiretroviral therapy in Malawi is based on a public health approach, with principles and practices borrowed from the successful World Health Organization "DOTS" tuberculosis control framework.

Background: Maternal morbidity and mortality among HIV-infected women is a global concern. This study compared mortality and health outcomes of HIV-infected and HIV-uninfected mothers at 18–20 months postpartum within routine prevention of mother-to-child transmission of HIV (PMTCT) services in a rural district in Malawi.

Background: Mother-to-child transmission of HIV (MTCT) remains the most prevalent source of pediatric HIV infection. Most PMTCT (prevention of mother-to-child transmission of HIV) programs have concentrated monitoring and evaluation efforts on process rather than on outcome indicators. In this paper, we review service data from 28,320 children born to HIV-positive mothers to estimate MTCT rates.

Purpose of review: This review focuses on current status, progress, challenges and opportunities in global pharmacovigilance for HIV/AIDS treatment.

Objective: The objective of this review is to produce evidence on the prevalence and trends in the availability of substandard and counterfeit antimicrobials in the global market and its consequences on key public health interventions in developing countries.

In 2004, Malawi began scaling up its national antiretroviral therapy (ART) program. Because of limited treatment options, population-level surveillance of acquired human immunodeficiency virus drug resistance (HIVDR) is critical to ensuring long-term treatment success. The World Health Organization target for clinic-level HIVDR prevention at 12 months after ART initiation is ≥70%.

Treatment as Prevention (TasP) describes HIV prevention methods that use antiretroviral therapy (ART) in both HIV-positive and HIV-negative persons to decrease the risk of HIV transmission.

This technical brief summarizes the latest evidence on PMTCT of HIV in the Southern African region. It presents the current WHO guidance on antiretroviral use in pregnant HIV-positive women: Options A, B and B+. Option B+ is a new development, emerging from experiences in Malawi, which was the focus of much attention at the recent International AIDS Conference.

This technical brief makes the case for understanding behavior change approaches as necessary but insufficient methods of HIV prevention. The document describes how behavior change interventions may be more effective when they are used as part of a  combination prevention approach that is shaped by a social-ecological perspective on HIV prevention.

In 2007, WHO/UNAIDS recommended that male circumcision be considered an important new intervention for HIV prevention, and that countries with a high HIV prevalence, low rates of male circumcision, and heterosexual epidemics should consider scaling up male circumcision as part of a comprehensive HIV prevention package.

We need a dramatic change in thinking—and action from donors, policymakers, and program managers in the public, private, and nongovernmental (NGO) sectors—to focus on strengthening health systems in the countries most affected by HIV & AIDS. To meet the Millennium Development Goal of reversing the epidemic by 2015, we must change how we design and deliver services.

These guidelines provide standards for HIV prevention program implementation for non-governmental organizations and civil society organizations, against which services provided to the target populations can be monitored and evaluated to ensure quality and client satisfaction.

INSIDE STORY tells the story of Kalu, a rising Kenyan footballer, who moves from rural Kenya to urban Johannesburg to follow his dream and support his family. His path becomes more challenging when he falls in love with the coach’s daughter Ify and subsequently finds out he is HIV-positive.

Mobile health (mHealth) is the provision of health services and information via mobile and wireless technologies. The mobile phone has become ubiquitous in Africa, making mHealth an important tool with which to impact the health of Africans. When applied correctly, mHealth can make real contributions to improved health outcomes. 

Nigeria is home to 17.5 million orphans and vulnerable children (OVC). According to the Federal Ministry of Women Affairs and Social Development, one in every four children in Nigeria is considered vulnerable due to unmet needs for nutrition, education, shelter, care, or support. The Need for New Solutions

In Nigeria, as in most countries, women and girls assume the bulk of the caregiving burden for those infected with HIV and children left vulnerable or orphaned by AIDS. These responsibilities often prevent girls and women from obtaining an education and developing income-generating skills.

In recent years, there has been a shift in how the international community is addressing the HIV epidemic. As more people are receiving antiretroviral therapy, we are seeing the benefits of reduced viral load on a population level. Fewer babies are being born HIV positive and prevalence rates are dropping in most countries with the highest HIV burdens.

This report reviews the role of mother mentors and their Mother Support Groups (MSGs) in supporting HIV-positive mothers to live healthy lives and use appropriate health services.