Trends in Tuberculosis Case Notification and Treatment Outcomes after Interventions in 10 Zones of Ethiopia

Journal Article
  • Z. G. Dememew
  • D. Habte
  • M. Muluken
  • S. D. Hamusse
  • G. Nigussie
  • N. Hiruy
  • B. Girma
  • Y. Kassie
  • Y. K. Haile
  • D. Jerene
  • P. Suarez
International Journal of Tuberculosis and Lung Disease
2016; Vol. 20, No. 9, pp. 1192-1198(7). DOI:


SETTING: Amhara and Oromia Regions, Ethiopia.
OBJECTIVE: To determine trends in case notification rates (CNRs) among new tuberculosis (TB) cases and treatment outcomes of sputum smear-positive (SS+) patients based on geographic setting, sex and age categories.
METHODS: We undertook a trend analysis over a 4-year period among new TB cases reported in 10 zones using a trend test, a mean comparison t-test and one-way analysis of variance.
RESULTS: The average CNR per 100 000 population was 128.9: 126.4 in Amhara and 131.4 in Oromia. The CNR in the project-supported zones declined annually by 6.5%, compared with a 14.5% decline in Tigray, the comparator region. TB notification in the intervention zones contributed 26.1% of the national TB case notification, compared to 13.3% before project intervention. The overall male-to-female ratio was 1.2, compared to 0.8 among SS+ children, with a female preponderance. Over 4 years, the cure rate increased from 75% to 88.4%, and treatment success from 89% to 93%. Default, transfer out and mortality rates declined significantly.
CONCLUSION: Project-supported zones had lower rates of decline in TB case notification than the comparator region; their contribution to national case finding increased, and treatment outcomes improved significantly. High SS+ rates among girls deserve attention.