MSH has been working in Lesotho primarily to support the country in its efforts against HIV and AIDS. Through the USAID-funded Systems for Improved Access to Pharmaceuticals and Services (SIAPS) Program, MSH works to ensure the availability of quality pharmaceutical products and services.

The program supports better use of data for decision-making in the supply chain management system, which has improved inventory control and supply planning. SIAPS has also installed RxSolution, an electronic inventory tracking system for pharmacies, in 17 hospitals across the country. SIAPS has worked with more than 1,700 workers to improve their pharmaceutical management skills, and with 134 laboratory workers to improve management information systems.

MSH has also works with Lesotho to strengthen its response to HIV and AIDS through the Building Local Capacity for Delivery of HIV Services (BLC) Project. BLC, funded by USAID, has provided technical assistance in leadership, management, and governance as well as organizational development.

BLC has also collaborated with partners to develop an early childhood care and development initiative, titled the Mphatlalatsane Project. the Mphatlalatsane Project aims to integrate HIV testing and treatment services, nutrition, and positive parenting practices for young children into rural communities via preschools.