counterfeit medicines

In this work, we demonstrate identity verification and concentration determination of pharmaceutical compounds via TLC using a custom 3D-printed cradle that interfaces with an ordinary mobile phone. Using single-component solutions of nevirapine, amodiaquine, and paracetamol that have been manually applied, the mobile phone-based detection instrument provides measurements that are equivalent to those obtained with a commercially available lab-based desktop TLC densitometer.

A thin-layer chromatography (TLC) method for the analysis of clotrimazole was developed and validated according to the International Conference on Harmonization and the United States Pharmacopeia guidelines. The developed method will be used for a qualitative and quantitative analysis of clotrimazole in vaginal tablets. The analytical method is useful for the determination of clotrimazole in the finished drug formulation. Also it helps to identify substandard and fake medicines labeled as clotrimazole during postmarketing surveillance of the drug and especially in resource-constrained countries.

Objective: The objective of this review is to produce evidence on the prevalence and trends in the availability of substandard and counterfeit antimicrobials in the global market and its consequences on key public health interventions in developing countries.

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