High-Performance Thin Layer Chromatography to Assess Pharmaceutical Product Quality

Journal Article
  • Eliangiringa Kaale
  • Vicky Manyanga
  • Narsis Makori
  • David Jenkins
  • Samuel Michael Hope
  • Thomas Layloff
Tropical Medicine & International Health
March 24, 2014; 19:6, pp. 747–51
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Abstract

Objective

To assess the sustainability, robustness and economic advantages of high-performance thin layer chromatography (HPTLC) for quality control of pharmaceutical products.

Method

We compared three laboratories where three lots of cotrimoxazole tablets were assessed using different techniques for quantifying the active ingredient.

Result

The average assay relative standard deviation for the three lots was 1.2 with a range of 0.65–2.0.

Conclusion

High-performance thin layer chromatography assessments are yielding valid results suitable for assessing product quality. The local pharmaceutical manufacturer had evolved the capacity to produce very high quality products.

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